Star Wars: The One Thing Stronger Than The Force Defeated Luke Skywalker - Easily
Time and time again, the Force has proven itself to be among the most ubiquitous concepts from "Star Wars" and one of the most powerful elements across the galaxy, even if interpretations on how the Force works have varied over the years. Whether it's a spiritual connection or a biological process involving midi-chlorians, Force-sensitive individuals can use it to influence reality to their will, affording them a tremendous amount of influence and power. However, there's actually an entity stronger than the Force that once sought to replace it, and even Luke Skywalker couldn't stop it himself.
One of the arcs in the canon 2020 comic series "Star Wars" sees a new malicious entity known as the Scourge plotting to take over the galaxy. A rogue droid with an extremely advanced artificial intelligence, the Scourge has the power to exert its will over other droids. The story features the Scourge using its influence to turn every entity across the galaxy in a collective consciousness, thereby supplanting the Force. In one climactic moment from "Star Wars" #41, Luke, Leia, and Lando fight off a horde of the Scourge's droids. Despite Luke's Force prowess, he and the rest of the group are overwhelmed and assimilated, leaving heroic droid Ajax Sigma to free them and their minds from the Scourge once again.
Some entities can beat out the Force
While the Scourge may be one of the greatest threats to ever rival the Force itself, there have been other terrifying creatures in the "Star Wars" universe that have shown themselves to be more powerful than the Force. The Nameless may be the most threatening of the bunch, as these monstrous beings have the power to track down Force-sensitive individuals, disrupt their connection to the Force, and feast on their life energy.
Other entities have historically demonstrated some level of immunity to the Force as well. The extra-galactic antagonists known as the Yuuzhan Vong seemingly exist outside of the Force, with most Jedi tactics proving ineffective against them. For some reason, Hutts like Jabba the Hutt also exhibit some resistance to the Force. It's unclear why certain "Star Wars" entities can reject the Force as opposed to others, but it's certainly a possibile in-universe.
All in all, the Force is an extremely strong power in the "Star Wars" universe — but it's not all powerful. Even the strongest of Force users like Luke Skywalker will have a difficult time facing off against foes like the Scourge or the Nameless if they're not incredibly careful.